Rh-Catalyzed Asymmetric Hydroformylation of Functionalized 1,1-Disubstituted Olefins

摘要

The first method for the highly enantioselec-tive rhodium-catalyzed hydroformylation of 1,1-disubstitut-ed olefins has been developed. By employing either of the P-chirogenic phosphine ligands BenzP~* and QuinoxP~*, linear aldehydes with β-chirality can be prepared in a highly enantioselective fashion with good chemo- and regioselectivities.