Synthesis of Functionalized 1H-lndenes via Copper-Catalyzed Arylative Cyclization of Arylalkynes with Aromatic Sulfonyl Chlorides

摘要

A variety of polysubstituted 1H-indenes can be prepared through the copper-catalyzed arylative cyclization of simple arylalkynes with commercially available aromatic sulfonyl chlorides that function as an aryl group donor. The reaction tolerates a broad range of functional groups, including bromide and iodide, nitrile, ketone, and nitro groups. The reaction allowed the synthesis of poly-cyclic aromatic hydrocarbons, such as a bis(indene), inda-cene, and fused polyarene derivatives, some of them showing strong fluorescence in solution and the solid state.