Oxidative Cycloaddition of 1,1,3,3-Tetramethyldisiloxane to Alkynes Catalyzed by Supported Gold Nanoparticles

摘要

Gold nanoparticles supported on TiO_2 (0.1—1% mol) catalyze at room temperature and at extremely mild conditions the unprecedented oxidative cycloaddition of 1,1,3,3-tetramethyldisiloxane to alkynes, forming substituted 2,5-dihydro-l,2,5-oxadisiloles, with concomitant evolution of hydrogen gas. For the majority of the substrates, the yields are exceptional (up to 99%). The reaction proceeds at room temperature, tolerates a variety of functional groups, and can be performed in several solvents.