Enantioselective Bromoaminocyclization Using Amino-Thiocarbamate Catalysts

摘要

A facile and efficient enantioselective bromoaminocyclization of unsaturated sulfonamides has been developed using an amino—thiocarbamate catalyst. A range of enantioenriched pyrrolidines were prepared with up to 99% yield and 99% ee. The corresponding lactams could be obtained through oxidation of the pyrrolidines.