Diastereoselectively Switchable Enantioselective Trapping of Carbamate Ammonium Ylides with Imines

摘要

The diastereoselectively switchable enantioselective trapping of protic carbamate ammonium ylides with imines is reported. The intriguing Rh_2(OAc)_4 and chiral Bronsted acid cocatalyzed three-component Mannich-type reaction of a diazo compound, a carbamate, and an imine provides rapid and efficient access to both syn- and anti-(X-substituted α, β-diamino acid derivatives with a high level control of chemo-, diastereo-, and enantioselectivity.