Synthetic Polymer Nanoparticles Conjugated with FimHA from E. coli Pili to Emulate the Bacterial Mode of Epithelial Internalization

Lily Yun Lin; Kristin M. Tiemann; Yali Li; Jerome S. Pinkner; Jennifer N. Walker; Scott J. Hultgren; David A Hunstad; Karen L. Wooley

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Synthetic Polymer Nanoparticles Conjugated with FimHA from E. coli Pili to Emulate the Bacterial Mode of Epithelial Internalization

机译：与大肠杆菌菌毛的FimHA偶联的合成聚合物纳米颗粒，模拟细菌上皮内在化的模式

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Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH_A through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.

机译：通过酰胺化化学将两亲性嵌段共聚物纳米颗粒与尿路致病性大肠杆菌1型菌毛粘附素FimH_A偶联，以使膀胱上皮细胞结合并在体外使纳米颗粒内在化。

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《Journal of the American Chemical Society》 |2012年第9期|p.3938-3941|共4页
作者
Lily Yun Lin; Kristin M. Tiemann; Yali Li; Jerome S. Pinkner; Jennifer N. Walker; Scott J. Hultgren; David A Hunstad; Karen L. Wooley;
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作者单位

Departments of Chemistry and Chemical Engineering, Texas A&M University, P.O. Box 30012, College Station, Texas 77842, United States;

Departments of Pediatrics Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, United States;

Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, United States;

Center for Molecular Imaging Research, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02129, United States;

Departments of Pediatrics Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, United States;

Center for Molecular Imaging Research, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02129, United States;

Departments of Pediatrics Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, United States,Center for Molecular Imaging Research, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02129, United States;

Departments of Chemistry and Chemical Engineering, Texas A&M University, P.O. Box 30012, College Station, Texas 77842, United States;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Pili Binding to Asialo-GM1 on Epithelial Cells Can Mediate Cytotoxicity or Bacterial Internalization byPseudomonas aeruginosa [J] . James C. Comolli, Leslie L. Waite, Keith E. Mostov, Infection and immunity . 1999,第7期

机译：菌毛结合上皮细胞上的Asialo-GM1可以介导铜绿假单胞菌的细胞毒性或细菌内在化。
2. Magnetic Polymeric Nanoparticles Functionalized by Mannose-Rhodamine Conjugate for Detection of E. coli [J] . Samon Trungkathan, Duangporn Polpanich, Srung Smanmoo, Journal of Applied Polymer Science . 2014,第6期

机译：甘露糖-若丹明缀合物功能化的磁性聚合物纳米颗粒用于检测大肠杆菌
3. Protectivity of Adhesion Molecules Pili 49,8 kDa Shigela dysenteriae Conjugated with ISCOM against Bacterial Colonization and Colonic Epithelial Cells Damage in Mice [J] . Dwi Setyorini, Yulian Dwi Utami, Edi Widjayanto, International Journal of Tropical Medicine . 2013,第1期

机译：粘附分子菌毛49,8 kDa痢疾志贺氏菌与ISCOM结合对小鼠细菌定殖和结肠上皮细胞损伤的保护作用
4. Effect of Commercially Available Synthetic Insulin on the Biofilm Formation in S. aureus and E. coli Bacterial Strains [C] . Jasmin Novalic, Berina Bektic International Conference on Medical and Biological Engineering . 2020

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5. Impacts of silver nanoparticles on bacterial species B. subtilis and E. coli and the major crop plant Z. mays. [D] . Doody, Michael A. 2014

机译：银纳米颗粒对细菌物种枯草芽孢杆菌和大肠杆菌以及主要农作物玉米的影响。
6. Synthetic polymer nanoparticles conjugated with FimHA from E. coli pili to emulate the bacterial mode of epithelial internalization [O] . Lily Yun Lin, Kristin M. Tiemann, Yali Li, -1

机译：来自大肠杆菌菌毛与FimHa缀合的合成聚合物的纳米颗粒来模拟上皮内的细菌模式
7. Gal-Gal pili vaccines prevent pyelonephritis by piliated Escherichia coli in a murine model. Single-component Gal-Gal pili vaccines prevent pyelonephritis by homologous and heterologous piliated E. coli strains. [O] . Pecha, B, Low, D, O'Hanley, P 1989

机译：Gal-Gal菌毛疫苗可在鼠模型中预防由毛发性大肠杆菌引起的肾盂肾炎。单组分Gal-Gal菌毛疫苗可通过同源和异源的大肠杆菌菌株预防肾盂肾炎。

Synthetic Polymer Nanoparticles Conjugated with FimHA from E. coli Pili to Emulate the Bacterial Mode of Epithelial Internalization

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