Synthetic polymer nanoparticles conjugated with FimHA from E. coli pili to emulate the bacterial mode of epithelial internalization

摘要

Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimHA through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.