Enantioselective Iron-Catalyzed Azidation of β-Keto Esters and Oxindoles

摘要

The first example of Fe-catalyzed enantioselective azidations of β-keto esters and oxindoles using a readily available N_3-transfer reagent is reported. A number of α-azido-β-keto esters were obtained with up to 93% ee, and this methodology also generates 3-substitued 3-azidooxindoles with high enantioselectivities (up to 94%).