Formal Carbene Insertion into C-C Bond: Rh(Ⅰ)-Catalyzed Reaction of Benzocyclobutenols with Diazoesters

摘要

A Rh(Ⅰ) -catalyzed formal carbene insertion into C-C bond of benzocyclobutenols has been realized by employing diazoesters as carbene precursors. The product indanol derivatives were obtained in good yields and in diastereoselective manner under mild reaction conditions. All-carbon quaternary center is constructed at the carbenic carbon. This catalytic reaction involves selective cleavage of C-C bond, Rh(Ⅰ) carbene insertion, and intramolecular aldol reaction.