FACILE APPROACH TO ENANTIOPURE HELICENES OVERCOMES LONG-STANDING CHALLENGE

摘要

Helicity is used to describe chiral molecules with helical, propeller, or screw-shaped geometry in the structures. It plays an important role in various fields of science, including biology, catalysis, material science, and nanoscience. Helicenes-helically chiral polyaromatics with angularly fused, overcrowded benzene rings-are perfect examples of helicity. However, their exotic geometry makes them extremely difficult targets for stereoselective synthesis, which has been one of the most challenging problems of helicene chemistry for more than half a century since their first discovery.