A facile solvent-free synthesis of chiral oxazolidinone derivatives catalyzed by MgI _2 etherate: An approach to enantiopure synthesis of linezolid

摘要

A highly efficient and stereoselective cycloaddition of aryl isocyanates with chiral oxiranes catalyzed by MgI _2 etherate under solvent-free conditions was developed to prepare the chiral oxazolidinone derivatives. This methodology has been applied into the practical synthesis of antibacterial drug linezolid.