EFFICIENT STRATEGY ENABLES LONG-SOUGHT SYNTHESES OF TETRAPETALONES A AND C

摘要

The tetrapetalones are naturally occurring polyketides with lipoxygenase-inhibiting activity. Their densely functionalized frameworks pose a significant synthetic challenge to organic chemists due to a β-linked rhodinose attached to a compact tetracyclic core embedded with a para-quinol and four contiguous stereocenters. While recent reports have disclosed elegant routes to tetrapetalone precursors, complete syntheses of the natural products have yet to be realized.