Recyclable Trifluoromethylation Reagents from Fluoroform

摘要

We present a strategy to rationally prepare CF_3 ~- transfer reagents at ambient temperature from HCF_(3.) We demonstrate that a highly reactive CF_3 ~- adduct can be synthesized from alkali metal hydride, HCF_3, and borazine Lewis acids in quantitative yield at room temperature. These nucleophilic reagents transfer CF_3 ~- to substrates without additional chemical activation, and after CF_3 transfer, the free borazine is quantitatively regenerated. These features enable syntheses of popular nucleophilic, radical, and electrophilic trifluoromethylation reagents with complete recycling of the borazine Lewis acid.