Nickel-Catalyzed Reductive Dicarbofunctionalization of Alkenes

摘要

An intermolecular, three-component reductive dicarbofunctionalization of alkenes is presented here. The combination of Ni catalysis with TDAE as final reductant enables the direct formation of Csp~3-Csp~3 and Csp~3-Csp~2 bonds across a variety of π-systems using two different electrophiles that are sequentially activated with exquisite selectivity under mild reaction conditions.