Ring Closing Metathesis Using Chiral Template Consisting of Hard and Soft Parts

摘要

Summary: Macrocyclic compounds having 18-, 19-, 22-, and 23-membered rings were prepared quantitatively by ring closing metathesis of diene substrates consisting of a rigid o- or m-phthalate group and flexible but geometrically regulated 2,4-pentanediol tethers. From the p-phthalate analogues, the ring closing metathesis and the cyclic dimmer formation were observed to give 24-membered ring (70% yield) and 40-membered ring (65% yield) respectively.