Synthesis and biological activity of some more heterocyclic compounds containing benzothiophene moiety

摘要

3-Chloro-1-benzothiophene-2-carbonylchloride 1 was allowed to react with hydrazine hydrate to give carbohydrazide 2. The reaction of 3-chloro-1-benzothiophene-2-carbohydrazide 2 with potassium thiocyanate gave compound 3, which was cyclized to form thioxotetrahydropyrimidine 4, thiazoles 5a-e, triazoles 7a-e and oxadiazoles 10a-h. The structures of all the synthesized compounds were confirmed by spectral data and have been screened for antimicrobial, analgesic and anthelmintic activities.