Chiral oxazolines in 1,3-dipolar cycloaddition reactions of azomethine ylides

摘要

Chiral oxazolines have been used as chiral auxiliaries in cycloaddition reactions of azomethine ylides generated from imines. Although cycloadducts were isolated in good yields, the stereoselectivity varied depending on the auxiliary structure. It has been demonstrated that a careful choice of the oxazoline auxiliary and the dipolarophile could lead to a high diastereoselectivity.