Performance of CFC free propellant- driven MDI of fluticasone propionate

摘要

Metered dose inhalers (MDIs) of fluticasone propionate were developed tor treatment of asthma and chronic obstructive pulmonary disease. MDIs with hydrofluoroalkanes based propellants were formulated with various doses, overages and various concentrations of alcohol. Optimum requirements were found as follows: effective valve delivery, overdoses (15%); 100% drug delivery, overages (20%); and emitted dose and fine particle fraction, alcohol content (5-10%).