Modeling and Control of Roller Compaction for Pharmaceutical Manufacturing Part II: Control System Design

摘要

Roller compaction is the major process of dry granulation which is attractive to heat or moisture-sensitive pharmaceutical products. Currently, the product quality of roller compaction is analyzed off-line in the quality control lab. In this work, we demonstrate how online process control can be applied on roller compaction using the simulator built in Part I of this paper. Different control strategies are discussed: multi-loop proportional–integral–derivative, linear model predictive control (MPC), and nonlinear MPC. The MPC strategy provides a systematic approach to design the multivariable control system. The simulation results show that the linear MPC can serve as a high-performance control strategy for roller compaction with the trade-off between the control performance and computational complexity. Such enhanced process control facilitates the FDA’s process analysis technology initiative.