Evaluation of short-term neurodevelopmental outcomes in the premature patients with periventricular-intraventricular hemorrhage

摘要

Abstract. Despite the significant advancements in perinatal care, it is not clear whether or not the neurodevelopmental outcomenin children with intraventricular hemorrhage (IVH) has improved in parallel with the declining incidence of periventricular-nIVH. In this study, we aimed to assess the periventricular-IVH-induced mortality and morbidity rates, as well as the short-termnneurodevelopmental outcomes in premature infants. Two hundred and sixty five patients who were admitted between Septembern2005 and May 2006 were investigated for periventricular-IVH. Sixty-six patients with periventricular-IVH were compared with 66npremature infants who were not associated with hemorrhage. Of the periventricular-IVH diagnosed premature infants, 59% werenborn at or before week 32, 61% had a body weight below 1500 g, and 24.9% had hemorrhage. In cases with periventricular-IVH,nthe rates of premature retinopathy and periventricular leukomalacia were significantly high (P <0.05). There was no statisticallynsignificant relation between periventricular-IVH and mortality (P > 0.05) while the relation between periventricular-IVH andnneuromotor developmental retardation was significant (P < 0.05). The outcome was poorer as the grade of bleeding increasedn(P <0.05). As a conclusion, regardless of risk factors, periventricular-IVH is an important early indicator of neurodevelopmentalnretardation, and those cases having such condition should be always assessed with a neurodevelopmental evaluation. The detectionnof neurodevelopmental retardation in short term with appropriate educational strategy could be beneficial for long-term outcome.