A Modified in Situ Suzuki Cross-Coupling of Haloarenes for the Preparation of C_2-Symmetric Biaryls

摘要

We have developed a one step modified in situ Suzuki coupling method for the production of C_2-symmetric biaryls which eliminates the need for boronic acid isolation. Moderate to excellent yields are obtained and a wide variety of functional groups are tolerated. Moreover, our in situ method is synthetically useful for the synthesis of natural products and the preparation of C_2-symmetric biaryl ligands.