Combinatorial synthesis of 2-thioxo-4-dihydropyrimidinones

摘要

Combinatorial methods of organic synthesis are now established as an important source of compound diversity for drug discovery. These libraries are usually prepared by solid-phase techniques, although solution-phase routes are attracting increasing attention. Recently, we re- ported the solution-phase synthesis of a thiohydantoin library from α-amino acids, aldehydes, and isothiocya- ates.