Radical fragmentation of β-hydroxy azides. Synthesis of chiral nitriles

摘要

In previous papers, we have described the preparation of chiral building blocks by fragmentation of anomeric alkoxy radicals of carbohydrates. Moreover, nitriles have provent to be extremely versatile functional groups. They may undergo a variety of reactions, especially Reduction, alkylation of their enolates, enzymatic hy- Drolysis to acide and amides by nitrile hydratase, Ritter Reaction, and many other synthetically useful transfor- Mations.