Asymmetric sulfoxidatio catalyzed by a vanadium-containing bromoperoxidase

摘要

A vanadium-containing bromoperoxidase (VbrPO) from the alga Corallina officinalis has been shown to catalyze the stereoselective oxidation of some aromatic bicycic sulfides to the corresponding (S)-sulfoxides in high (up to 91/100) ee. Hydrogen peroxide was found to have a large effect on the catalyzed reaction, most likely due to an inhibition of VbrPO. High optical and chemical yields with found to be favored by a continuous slow addition of hydrogen peroxide to keep a low excess.