Nickel- vs palladium-catalyzed synthesis of protected phenols from aryl halides

摘要

We report the nickel-catalyzed formation of alkyl and silyl ethers from aryl halides in one step. These ethers can act as precursors to phenols by reaction with Bronsted or Lewis acids or with Fluoride, A combination of Ni(COD)_2 and DPPF mediates the formation of tert-butyl aryl, methyl Aryl, and tert-butyldimetryl silyl aryl ethers efficiently from aryl halides and sodium alkloxides or Soldium siloxides under mild reaction conditions.