New application of the pummerer reaction of lidosulfoxides for the generation of mesoionic dipoles

摘要

α-Acyl thionium ions generated from α-acyl sulfoxides under Pummerer conditions are powerful electophiles, reacting efficiently with variety of nucleophilic sepcies. Bimolecular addition of these types of cations to carbon- Carbon double bonds is well known. In the realm of Natural product synthesis, most success has been achieved Using intramolecular Friedel-Crafts cyclization of the Pummeret thionium ion intermediate.