A Mild, Pyridine-Borane-Based Reductive Amination Protocol

摘要

The in situ reductive amination of ketones or aldehydes has been an important part of the synthetic chemist's repertoire since the introduction of a procedure based on cyanoborohydride, yet the toxicity and disposal problems associated with this material has led to a continuing search for alternative reductants. We would like to report a simple and mild in situ reductive amination protocol using methanolic pyridine-borane and 4 A molecular sieves.