PREPARATION OF A SEMISYNTHETIC ANALOGUE OF MEVINOLIN AND COMPACTIN

Clive DLJ.; Dasilva GVJ.; Wickens PL.

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PREPARATION OF A SEMISYNTHETIC ANALOGUE OF MEVINOLIN AND COMPACTIN

机译：甲胎蛋白和紧密连接蛋白半合成类似物的制备

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摘要

Enone 5, derived by chemical degradation of compactin (1), was elaborated into the semisynthetic analogue 4, which is an inhibitor of cholesterol biosynthesis in rat liver microsomes. [References: 31]

机译：将通过压制紧密蛋白（1）的化学反应而得的Enone 5合成为半合成类似物4，该半合成类似物4是大鼠肝脏微粒体中胆固醇生物合成的抑制剂。 [参考：31]

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《The Journal of Organic Chemistry》 |1995年第17期|p. 5532-5536|共5页
作者
Clive DLJ.; Dasilva GVJ.; Wickens PL.;
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作者单位

UNIV ALBERTA DEPT CHEM EDMONTON AB T6G 2G2 CANADA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类有机化学;
关键词
Coa reductase inhibitors; Silyl enol ethers; Tert-butyl sulfides; Seco-mevinic acids; Alpha-arylation; Ketones; Reagents; Vinyloxiranes; Phenylation;

机译：Coa还原酶抑制剂;甲硅烷基烯醇醚;叔丁基硫化物;癸-甲羟乙酸;α-芳基化;酮;试剂;乙烯基环氧乙烷;苯基化;

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专利

1. STUDIES ON THE DEGRADATION OF MEVINOLIN AND COMPACTIN - A FORMAL ROUTE TO SEMISYNTHETIC ANALOGUES [J] . Clive DLJ., Zhang CZ. The Journal of Organic Chemistry . 1995,第5期

机译：甲萘威林和紧密素的降解研究-半合成拟模的正式路线。
2. CHIRAL SULFOXIDES IN ASYMMETRIC SYNTHESIS - ENANTIOSELECTIVE SYNTHESIS OF THE LACTONIC MOIETY OF (+)-COMPACTIN AND (+)-MEVINOLIN - APPLICATION TO A COMPACTIN ANALOGUE [J] . Solladie G, Bauder C, Rossi L The Journal of Organic Chemistry . 1995,第24期

机译：不对称合成中的手性硫辛酸酯-（+）-蛋白和（+）-甲萘菌素的Latonic部分的对映体选择性合成-在COMPACTIN类似物中的应用
3. Co-catalyzed two-stereocentered hydrolytic kinetic resolution: application to the synthesis of yashabushidiols A and B and the lactone unit of compactin and mevinolin [J] . Gadakh Sunita K., Sudalai Arumugam Tetrahedron, Asymmetry: The International Journal for Repid Publication on all Aspects of Asymmetry in Orgainc, Inorganic, Organometallic, Physical and Bio-Organic Chemistry . 2015,第2a3期

机译：共催化的两个立体中心的水解动力学拆分：在合成矢车菊二醇A和B以及紧密蛋白和美维林的内酯单元中的应用
4. Preparation of New 5-Methylthio-6-nitro-1,2,4-triazolo 1,5-apyrimidine-7-ones as Structural Analogues of Antiviral Drugs [C] . D.N. Lyapustin, E.N. Ulomsky, E.K. Voinkov, International Conference on Modern Synthetic Methodologies for Creating Drugs and Functional Materials . 2019

机译：制备新的5-甲基-6-硝基-1,2,4-三唑唑1,5-a嘧啶-7-抗病毒药物的结构性类似物
5. Semisynthetic betulin analogues with potential biodynamic activity. [D] . Huang, Fu-Yung. 1988

机译：具有潜在生物动力活性的半合成白桦蛋白类似物。
6. Biological Profiling of Semisynthetic C19-Functionalized Ferruginol and Sugiol Analogues [O] . Miguel A. González-Cardenete, Fatima Rivas, Rachel Basset, 2021

机译：半合成的C19官能化铁蛋白和脂肪醇类似物的生物分析
7. Solistatinol, a novel phenolic compactin analogue from Penicillium solitum [O] . Larsen Thomas Ostenfeld, Lange Lene, Schnorr Kirk, 2007

机译：solistatinol，一种来自penicillium solitum的新型酚类紧密蛋白类似物

PREPARATION OF A SEMISYNTHETIC ANALOGUE OF MEVINOLIN AND COMPACTIN

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