Diastereoselective Synthesis of Trisubstituted Cyclopentane- and Cyclohexanecarboxylic Acid Derivatives Mediated by Iron Tricarbonyl

摘要

We have provided an effective method for the formation of trisubstituted five- and six-membered carboxylic acid derivatives which invokes the intramolecular cyclization/oxidation of (η~4-diene)Fe(CO)_3 complexes bearing a functionalized side chain. The ability to achieve the exclusive diastereocontrol in all cases may have further applications. Specifically, the preparation of even more densely substituted templates for natural product synthesis would be expected to demonstrate still higher levels of stereocontrol.