Highly regio- and stereoselective synthesis of polysubstituted cyclopropane compounds via the Pd(O)-catalyzed coupling-cyclization reaction of 2-(2 ',3 '-allenyl)malonates with organic halides

Ma SM; Jiao N; Yang Q; Zheng ZL

首页> 外文期刊>The Journal of Organic Chemistry >Highly regio- and stereoselective synthesis of polysubstituted cyclopropane compounds via the Pd(O)-catalyzed coupling-cyclization reaction of 2-(2 ',3 '-allenyl)malonates with organic halides

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Highly regio- and stereoselective synthesis of polysubstituted cyclopropane compounds via the Pd(O)-catalyzed coupling-cyclization reaction of 2-(2 ',3 '-allenyl)malonates with organic halides

机译：通过Pd（O）催化2-（2'，3'-烯基）丙二酸酯与有机卤化物的偶联-环化反应，高度区域选择性地合成多取代的环丙烷化合物

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摘要

A new method for highly regio- and stereoselective synthesis of polysubstituted cyclopropane compounds via the Pd(0)-catalyzed coupling-cyclization reaction of 2-(2',3'-allenyl)malonates with organic halides is described. In these reactions, the starting materials are easily available and the operation is convenient. The ratios of trans-isomer/ cis-vinylic cyclopropanes are up to 98:2.

机译：描述了一种新的方法，用于通过2-（2'，3'-烯基）丙二酸酯与有机卤化物的Pd（0）催化偶联-环化反应，对区域高度立体选择性合成多取代的环丙烷化合物。在这些反应中，原料容易获得并且操作方便。反式异构体/顺式-乙烯基环丙烷的比例高达98：2。

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来源
《The Journal of Organic Chemistry》 |2004年第19期|p. 6463-6466|共4页
作者
Ma SM; Jiao N; Yang Q; Zheng ZL;
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作者单位

Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类有机化学;
关键词
PALLADIUM-CATALYZED HETEROANNULATION; FUNCTIONALLY-SUBSTITUTED ARYL; ALLENES; CARBOPALLADATION; DERIVATIVES; CARBOANNULATION; 1; 2-DIENES; IODIDES; ROUTE; RINGS;

机译：钯催化的异氰酸酯化;功能取代的芳基;异戊二烯;羰基化;衍生物;碳环化;1;2-二烯;碘化物;路线;环;
入库时间 2022-08-18 00:03:30

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Highly regio- and stereoselective synthesis of polysubstituted cyclopropane compounds via the Pd(O)-catalyzed coupling-cyclization reaction of 2-(2 ',3 '-allenyl)malonates with organic halides

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