New Piperidine Scaffolds via Nucleophilic Reactivity of (―) -Phenyloxazolopiperidine

摘要

The present work illustrates the power of compound 2 as a chiral, nonracemic, and stable 2-piperideine (enamine) equivalent in the rapid and efficient construction of 3-substituted piperidines (carbon―carbon and carbon―sulfur bonds) such as 3-spiropiperidines. This methodology offers a new route to such systems that could compete with previously reported strategies.