Synthesis of Cytochrome c Oxidase Models Bearing a Tyr~(244) Mimic

摘要

A close structural analogue of the metal-free cytochrome c oxidase active site has been synthesized. This model has a proximal imidazole tail and three distal imi-dazole pickets attached to a porphyrin. One distal imidazole is cross-linked to a phenol, mimicking Tyr~(244). The strategy behind the successful synthesis of this regioisomerically pure model involved discovering the best sequence to introduce the phenol-substituted imidazole and employing a fluorinated substituent.