Kumada Coupling of Aryl and Vinyl Tosylates under Mild Conditions

摘要

Aryl and alkenyl tosylates are easily prepared,inexpensive and,thus,attractive for transition-metal-catalyzed couplings,but their reactivity is low.We report examples of mild,palladium-catalyzed coupling of aryl,alkenyl,and alkyl Grignard reagents with aryl and alkenyl tosylates.The resulting biaryls,vinylarenes,and alkylarenes were isolated in good to excellent yield.These couplings were conducted with a nearly equimolar ratio of the two reactants,and many examples were conducted at room temperature.