Preparation and Synthetic Application of a Novel Ketene Silyl Acetal of Methyl Trifluoropyruvate

摘要

A novel trifluoromethyl ketene silyl acetal(4)of methyl trifluoropyruvate(1)was prepared in 82% yield by metal Mg reduction in a(TMS)C1/THF system.Subsequent carbon-carbon bond formation such as Mukaiyama aldol,Michael addition,and other nucleophilic reactions of 4 at the trifluoromethylated carbon with various electrophiles gave various coupling products in high yields.