Total Synthesis of (+)-Crocacin D

摘要

The total synthesis of (+)-crocacin D is described.The convergent asymmetric synthesis relies on the use of a Stille cross-coupling between an (E)-vinyl stannanc with an (E)-vinyl iodide to establish the (E,E)-dieriamide moiety followed by a mild and efficient copper-catalyzed coupling between ( - )-crocacin C and a (Z)-vinyl iodide to establish the challenging (Z)-cnamide function.