Synthetic Approaches and Total Synthesis of Natural Zoapatanol

摘要

The total synthesis of (+)-zoapatanol utilizing an intramolecular Horner-Wadsworth-Emmons olefination and an enantioselective Sharpless dihydroxylation as the key steps has been achieved.An advanced oxepene intermediate has been obtained by applying a ring-closing metathesis to an unsaturated enol ether.