Absolute Configuration of 2-(Tributylstannyl)pyrrolidine by Anomalous Dispersion X-ray Analysis

摘要

Enantiopure 2-(tributylstannyl)pyrrolidine hydroiodide may be prepared in excellent yield by TMSI treatment of the corresponding iV-Boc compound,which is in turn prepared by asymmetric deprotonation(s-BuLi-sparteine)and stan-nylation,as described in the literature.Crystals of the hydroiodide salt suitable for X-ray analysis were obtained,and although there is some disorder about the butyl groups,analysis using anomalous dispersion establishes the absolute configuration as S.