Highly Enantioselective α-Aminoxylation of Aldehydes and Ketones in Ionic Liquids

摘要

As the first example for the synthesis of optically active α-hydroxyaldehydes and a-hydroxyketones in ionic liquids, we applied RTILs into L-proline catalyzed direct enantioselective α-aminoxylation of both aldehydes and ketones successfully. This protocol features a number of advantages, such as recycling of green solvents and chiral organocatalyst, high yields, excellent enantioselectivities, short reaction times, and broad substrate scope.