A Simple,Two-Step,Site-Specific Preparation of Fluorinated Naphthalene and Phenanthrene Derivatives from Fluorobromo-Substituted Alkenes

摘要

A facile two-step procedure for the site-specific preparation of fluorinated naphthalene and phenanthrene derivatives is described.The Sonogashira reaction of bromofluoro-substituted alkenes with terminal alkynes,followed by base-catalyzed cyclization in refluxing N-methyl-2-pyrrolidinone (NMP),affords the corresponding fluorinated naphthalene and phenanthrene derivatives in good yields.