A General Modular Method of Azaindole and Thienopyrrole Synthesis via Pd-Catalyzed Tandem Couplings of gem -Dichloroolefins

摘要

A palladium-catalyzed reaction of gem-dichloroolefins and a boronic acid via a tandem intramolecular C—N and intermolecular Suzuki coupling process gave corresponding substituted azaindoles or thienopyrroles. This method is a very modular protocol to synthesize all four isomers of azaindole and two isomers of thienopyrroles in good to excellent yield.