Aminoindolines versus Quinolines: Mechanistic Insights into the Reaction between 2-Aminobenzaldehydes and Terminal Alkynes in the Presence of Metals and Secondary Amines

摘要

DFT computational studies in the cyclization ofnaminoalkyne (see structure), which is generated in situ by 2-naminobenzaldehydes and terminal alkynes in the presence ofnmetals and secondary amines, has been investigated. The studynrevealed that the mode of cyclization (exo vs endo) depends onnthe protecting group on nitrogen, the oxidation state ofncopper, and substitution on alkyne.