Construction of Multisubstituted Tetrahydropyrans by a Domino Oxa-Michael/Tsuji?Trost Reaction

摘要

Biologically significant tetrahydropyrans (THP) werensynthesized by a Tandem oxa-Michael/Tsuji−Trost reaction. DifferentnMichael acceptors were investigated, and optimal results in termsnof diastereoselectivities and yields were obtained with nitro olefins.nThe influence of the reaction parameters, substrate patterns, and typenof metal counterions on the yield and stereochemical outcome of thisnprocess is discussed, and an explanation for the observed stereoselectivitiesnis proposed.