Characterizing the normal range of myocardial blood flow with 82rubidium and 13N-ammonia PET imaging

摘要

Background Diagnosis of coronary disease and microvascular dysfunction may be improved by comparing myocardial perfusion scans with a database defining the lower limit of normal myocardial blood flow and flow reserve (MFR). To maximize disease detection sensitivity, a small normal range is desirable. Both 13N-ammonia and 82Rb tracers are used to quantify blood flow and MFR using positron emission tomography (PET). The goal of this study was to investigate the trade-off between noise and accuracy in both 82Rb and 13N-ammonia normal databases formed using a net retention model.