JNCL patients show marked brain volume alterations on longitudinal MRI in adolescence

T. H. Autti PhD MD; J. H?m?l?inen MSc; M. Mannerkoski MD; K. Van Leemput PhD; L. E. ?berg MD PhD

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JNCL patients show marked brain volume alterations on longitudinal MRI in adolescence

机译：JNCL患者在青春期纵向MRI上显示明显的脑容量改变

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摘要

Juvenile neuronal ceroid lipofuscinosis (JNCL, CLN3) is an inherited lysosomal disease. We used longitudinal MRI, for the first time, to evaluate the rate of brain volume alterations in JNCL.

机译：青少年神经元类脂褐藻病（JNCL，CLN3）是遗传性溶酶体病。我们首次使用纵向MRI来评估JNCL中脑体积改变的速率。

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来源
《Journal of Neurology》 |2008年第8期|1226-1230|共5页
作者
T. H. Autti PhD MD; J. H?m?l?inen MSc; M. Mannerkoski MD; K. Van Leemput PhD; L. E. ?berg MD PhD;
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作者单位

Helsinki Medical Imaging Center Helsinki University Central Hospital 340 00029 HUS Finland;

Helsinki Medical Imaging Center Helsinki University Central Hospital 340 00029 HUS Finland;

Helsinki Medical Imaging Center Helsinki University Central Hospital 340 00029 HUS Finland;

Helsinki Medical Imaging Center Helsinki University Central Hospital 340 00029 HUS Finland;

Hospital for Children and Adolescents Pediatric Neurology University of Helsinki Helsinki Finland;

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原文格式 PDF
正文语种 eng
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关键词
NCL; JNCL; CLN3; brain; MRI;

机译：NCL;JNCL;CLN3;脑;MRI;

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专利

1. JNCL patients show marked brain volume alterations on longitudinal MRI in adolescence. [J] . Autti TH, Hamalainen J, Mannerkoski M, Journal of neurology . 2008,第8期

机译：JNCL患者在青春期纵向MRI上显示出明显的脑容量改变。
2. The role of testosterone and estradiol in brain volume changes across adolescence: A longitudinal structural MRI study [J] . Human brain mapping . 2014,第11期

机译：睾丸激素和雌二醇在青春期大脑体积变化中的作用：一项纵向结构MRI研究
3. Longitudinal changes in brain volumes and cerebrovascular lesions on MRI in patients with manifest arterial disease: The SMART-MR study [J] . VanDerVeenP.H., MullerM., VinckenK.L., Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology . 2014,第1a2期

机译：明显动脉疾病患者MRI的脑容量和脑血管病变的纵向变化：SMART-MR研究
4. Non-invasive monitoring of cortical volume alterations in rat brains using a clinical 3T whole body MRI scanner [C] . K.-H. Herrmann, S. Schmidt, M. Metzler, World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

机译：使用临床3T全身MRI扫描仪无创监测大鼠大脑皮层体积变化
5. Longitudinal Brain Tumor Tracking, Tumor Grading, and Patient Survival Prediction Using MRI [D] . ?Pei, Linmin 2020

机译：使用MRI纵向脑肿瘤跟踪，肿瘤分级和患者存活预测
6. The role of testosterone and estradiol in brain volume changes across adolescence: a longitudinal structural MRI study [O] . M.M. Herting, P. Gautam, J.M. Spielberg, 2014

机译：睾丸激素和雌二醇在青春期大脑体积变化中的作用：一项纵向结构MRI研究
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JNCL patients show marked brain volume alterations on longitudinal MRI in adolescence

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