Multidrug Resistance-Associated Protein MRP1 Expression in Human Gliomas: Chemosensitization to Vincristine and Etoposide by Indomethacin in Human Glioma Cell Lines Overexpressing MRP1

摘要

The 190 kDa multidrug resistance protein MRP1 is likely to be involved in the multidrug resistance phenotype of human gliomas. MRP1 expression was evaluated in surgical tumor samples from 17 patients with gliomas. In addition, the impact of the MRP's inhibitor, indomethacin, on the chemosensitivity to etoposide (VP16) and vincristine (VCR) of two glioblastoma cell lines expressing MRP1 (GL15 and 8MG) was investigated.