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HMGA1 expression in human gliomas and its correlation with tumor proliferation, invasion and angiogenesis

机译：HMGA1在人胶质瘤中的表达及其与肿瘤增殖，侵袭和血管生成的关系

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摘要

High-mobility group A1 (HMGA1) protein is an architectural transcription factor widely expressed during embryonic development and tumor progression. The purpose of this research was to investigate the expression of HMGA1 in malignant gliomas with different WHO classification and to study the correlation of HMGA1 expression with tumor proliferation, invasion, and angiogenesis. Expression of HMGA1, Ki-67, MMP-9, VEGF-A, and MVD in malignant gliomas and their correlation were studied in 60 samples of different WHO classification by use of immunohistochemistry, and in 27 randomly selected samples by use of real-time quantitative PCR. Immunohistochemistry results showed that nuclear immunostaining of HMGA1 protein was not observed in normal brain tissues but was observed in 96.7% (58 of 60) of malignant gliomas including high (+++) in 15 (25.0%), moderate (++) in 28 (46.7%), and negligible to low (0–+) in 17 (28.3%) samples. Expression of HMGA1 protein was significantly higher in glioblastoma multiforme than in WHO grade II (P = 0.002) and WHO grade III gliomas (P = 0.024). HMGA1 protein expression correlated significantly with expression of Ki-67 (r = 0.530, P = 0.000), MMP-9 (r = 0.508, P = 0.000), VEGF-A (r = 0.316, P = 0.014), and MVD (r = 0.321, P = 0.012), but not with sex (r = 0.087, P = 0.510) and age (r = −0.121, P = 0.358). Real-time quantitative PCR results, also, were indicative of HMGA1 overexpression in glioblastoma multiforme compared with WHO grade II (P = 0.043) and WHO grade III (P = 0.031) gliomas. HMGA1 gene expression correlated significantly with gene expression of Ki-67 (r = 0.429, P = 0.025), MMP-9 (r = 0.443, P = 0.024), and VEGF-A (r = 0.409, P = 0.034). These results indicated that expression of HMGA1 correlates significantly with malignancy, proliferation, invasion, and angiogenesis of gliomas. We conclude that HMGA1 may be a potential biomarker and rational therapeutic target for human tumors.
机译：高迁移率A1组蛋白（HMGA1）是一种在胚胎发育和肿瘤进展过程中广泛表达的结构转录因子。这项研究的目的是调查HMGA1在具有不同WHO分类的恶性神经胶质瘤中的表达，并研究HMGA1表达与肿瘤增殖，侵袭和血管生成的相关性。 HMGA1，Ki-67，MMP-9，VEGF-A和MVD在恶性神经胶质瘤中的表达及其相关性在60种不同WHO分类的样本中通过免疫组织化学研究，在27种随机选择的样本中通过实时分析。定量PCR。免疫组织化学结果显示，在正常脑组织中未观察到HMGA1蛋白的核免疫染色，但在96.7％（60个中的58个）恶性神经胶质瘤中观察到了，其中15个（25.0％）高（+++），中等（++）高28（46.7％），在17（28.3％）个样本中低到（0+）可以忽略不计。 HMGA1蛋白的表达在多形性胶质母细胞瘤中明显高于WHO II级（P = 0.002）和WHO III级神经胶质瘤（P = 0.024）。 HMGA1蛋白表达与Ki-67（r = 0.530，P = 0.000），MMP-9（r = 0.508，P = 0.000），VEGF-A（r = 0.316，P = 0.014）和MVD的表达显着相关（ r = 0.321，P = 0.012），但不包括性别（r = 0.087，P = 0.510）和年龄（r = −0.121，P = 0.358）。实时定量PCR结果也表明，与WHO II级（P = 0.043）和WHO III级（P = 0.031）神经胶质瘤相比，多形性胶质母细胞瘤中HMGA1过表达。 HMGA1基因表达与Ki-67（r = 0.429，P = 0.025），MMP-9（r = 0.443，P = 0.024）和VEGF-A（r = 0.409，P = 0.034）的基因表达显着相关。这些结果表明，HMGA1的表达与神经胶质瘤的恶性，增殖，侵袭和血管生成显着相关。我们得出结论，HMGA1可能是人类肿瘤的潜在生物标志物和合理的治疗靶标。

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  • 来源
    《Journal of Neuro-Oncology》 |2012年第3期|p.543-549|共7页
  • 作者

    Bo Pang; Haitao Fan; Ian Y. Zhang; Bin Liu; Bin Feng; Lei Meng; Rui Zhang; Sam Sadeghi; Hua Guo; Qi Pang;

  • 作者单位

    Shandong University School of Medicine, Jinan, 250012, People’s Republic of China;

    Shandong University School of Medicine, Jinan, 250012, People’s Republic of China;

    Department of Neurosurgery, City of Hope, Duarte, CA, 91010, USA;

    Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, 250021, People’s Republic of China;

    Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, 250021, People’s Republic of China;

    Department of Neurosurgery, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250013, People’s Republic of China;

    Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, 250021, People’s Republic of China;

    Department of Neurosurgery, City of Hope, Duarte, CA, 91010, USA;

    Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, 250021, P;

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  • 正文语种 eng
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  • 关键词

    Glioma; High-mobility group A1 (HMGA1); Proliferation; Invasion; Angiogenesis;

    机译：胶质瘤;高流动性A1组（HMGA1）;增殖;侵袭;血管生成;

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