Codon 201 Mutation of DCC Gene and Tumor Biologic Behavior in Human Colorectal Carcinoma

摘要

To explore the relationship between a point mutation of codon 201 in deleted in colorectal carcinoma (DCC) gene and the biological behavior of colorectal carcinoma. Meth - ods Tumor tissues and matched abjacent normal colon mucosa collected in 35 patients during surgical resection for colorectal carcinoma were analyzed. Forty normal colon mucosa tissues obtained by biopsy from patients who had neither colorectal tumor nor a family history of colorectal cancer during colonscop - ic examination were used as control.