Antibodies to surface IgD can accelerate apoptosis of mature b- lymphocyes at sub-stimulatory concentratons

摘要

Antibody to B-cell surface immunoglobulin D (IgD) or surface IgM results in crosslinking of Ig molecules and signal transduction. The function of these surface immunoglobulins has traditionally been investigated by extensive crosslinking experiments and interest has been focused on activation assays. We investigated the effects on apoptosis of culture with anti-μ antibody (anti-μ) concentrations ranging from 0.001 μg mL~-1 to 50 μg mL~-1. Previous experiments have shown that weak dose anti-δ antibody (anti-δ) increase mature B-cell apoptosis at both 16- and 64-hour time points, while greater dose anti-δ results in cell cycle entry at 64 hours.