Time-dependent changes of astrocytes following microinjection of kainic acid and irradiation by gamma-knife in adult rat brain

摘要

Objective: Two groups of rats were microinjected with kainic acid (KA) and irradiated with gam- ma knife respectively on unilateral nucleus caudate-putamen to compare the response of astrocytes. Methods: The astrocytes were identified with anti-GFAP immunohistochemical ABC method and the progress of their Reaction to the 2 insults was examined from 3 h to 30 d after the lesion. Results: Both lesions could induce Hyperplasia and hypertroph of rastrocytes and 2 types of GFAP-ir cells were found, one with small cell body And thin process, and the other with hyperptrophic cell body and thick and long process.