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Expression of the novel gene NM23-H1B in ovarian cancer

机译:新基因NM23-H1B在卵巢癌中的表达

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Objective: To study the expression of the human novel gene NM23-H1B in ovarian cancer. Methods: Totally 24 samples from patients with epithelial ovarian tumor at different clinical stages and 4 from normal ovaries were examined for NM23-H1B mRNA expression by RT-PCR and Northern blot. Results : All samples expressed NM23-H1B mRNA through RT-PCR, while the level of expression in ovarian tumor was higher than that of normal ovary. The results of Northern blot showed that NM23-H1B was overexpressed in ovarian cancer while lowexpressed in normal ovary or low malignant potential (LMP). The level of expression at early stage cancer (stage Ⅰ and Ⅱ ) was higher than those in advanced cancer (stage Ⅲ and Ⅳ ). In early stage carcinoma, the expression level was involved in the differentiation of tumor cell, and well-differentiated cancer expressed NM23-H1B mRNA in comparatively higher level. Conclusion; The novel gene NM23-N1B is closely correlated with the ovarian cancer.
机译:目的:研究人新基因NM23-H1B在卵巢癌中的表达。方法:采用RT-PCR和Northern blot方法检测24例不同临床分期的卵巢上皮性肿瘤患者和4例正常卵巢的患者NM23-H1B mRNA的表达。结果:所有样品均通过RT-PCR表达NM23-H1B mRNA,而卵巢肿瘤中的表达水平高于正常卵巢。 Northern印迹的结果表明,NM23-H1B在卵巢癌中高表达,而在正常卵巢或低恶性潜能(LMP)中低表达。早期癌症(Ⅰ和Ⅱ期)的表达水平高于晚期癌症(Ⅲ和Ⅳ期)。在早期癌中,表达水平与肿瘤细胞的分化有关,分化良好的癌组织中NM23-H1B mRNA的表达相对较高。结论;新基因NM23-N1B与卵巢癌密切相关。

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